N-Methylpiperazine is important intermediate for organic synthesis.  It can be used to produce antibacterial rifampicin, antipsychotic trifluoperazine, ofoxacin, etc in pharmaceutical industry.

N-Methylpiperazine reacts with Benzene, 1-fluoro-4-nitro-; Naphthalene, 1-[(chloromethyl)sulfonyl]-; Benzene, 1-chloro-3-(chloromethyl)-; 1,8-Naphthalenediamine to 1H-Indazole, 1-[(3-chlorophenyl)methyl]-3-(1-naphthalenylsulfonyl)-5-(1-piperazinyl)-, hydrochloride (1:2). N-Methylpiperazine can be used as reagent in processing of Thieno[3,2-b]pyridine-6-carboxylic acid, 4,7-dihydro-7-oxo-.N-Methylpiperazine(109-01-3) can be used as solvent in processing of 1,8-Naphthyridin-4(1H)-one, 2,3-dihydro-7-(4-methyl-1-piperazinyl)-, O-(1,3-benzodioxol-5-ylmethyl)oxime, (4E)-.